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Zooey Deschanel and Jake Johnson -

When it comes to the hit sitcom 'New Girl,' Jessica and Nick were the couple that was always meant to be. Fans rooted for them throughout all seven seasons, and the writers managed to drag their love story out for years. In the new podcast 'Welcome to Our Show,' which features Deschanel and two of her co-stars discussing all the behind-the-scenes magic, Deschanel revealed that the chemistry between her and Jake Johnson was palpable on set. In fact, the writers actually told her that they had "too much" chemistry! This led them to separate Nick and Jess's storylines so they could allow the relationship to develop more slowly over several seasons. 

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Sandra Bullock and Keanu Reeves -

Sandra Bullock and Keanu Reeves starred together in the movies 'Speed' (1994) and 'The Lake House' (2006). Their romances were so believable that fans speculated for years it was more than acting. Bullock addressed the rumors once and for all in a recent interview with Esquire and stated unequivocally that they'd never dated. However, she did reveal to Ellen DeGeneres in 2018 that she had a crush on Reeves when they were filming 'Speed.' When Reeves was asked if had been aware of this he said no, and added: "She obviously didn't know I had a crush on her either."

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Jessica Chastain and Oscar Isaac -

Chastain and Isaac already appeared as a couple in the 2014 film 'A Most Violent Year,' and are co-starring in the new HBO miniseries 'Scenes From a Marriage.' While some might speculate a sexual connection between the two, Chastain clarified that they've been good friends for more than half of their lives. They went to college together and are extremely close, which is why they seem so comfortable and playful with each other. 

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Lady Gaga and Bradley Cooper - Oscar-winning Gaga and Cooper's chemistry was so strong in 'A Star is Born,' that the pair has been rumored to be secretly in love.

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Brad Pitt and Angelina Jolie - One of the most famous Hollywood couples got together on the set of 'Mr. and Mrs. Smith' in 2005, and reunited on-screen in 'By the Sea' ten years later.

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Leonardo DiCaprio and Kate Winslet - Of course the instantly iconic couple from 'Titanic' makes the list, and even though their 2008 film 'Revolutionary Road' didn't do nearly as well, it took courage to reunite on-screen.

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Tom Cruise and Nicole Kidman -

Cruise and Kidman's on- and off-screen romance was huge in the '90s, as they starred in three films together. The last of which, 'Eyes Wide Shut', is often suspected as a major factor in the dissolution of their marriage.

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Emma Stone and Ryan Gosling - Before they won hearts in 'La La Land,' they made everyone swoon at the 'Dirty Dancing' lift in 'Crazy, Stupid Love.'

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Julia Roberts and Richard Gere -

Roberts and Gere's on-screen chemistry in 'Pretty Woman' and 'Runaway Bride' was visible.

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Kristen Stewart and Robert Pattinson - The 'Twillight' couple had to make this list. They eventually became a couple in real-life, but unfortunately they're no longer together.

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Patrick Swayze and Demi Moore - The pair had an amazing on-screen chemistry in 'Ghost.' Supernatural love is still love, right? 

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Ryan Gosling and Rachel McAdams - The romance between Gosling and McAdams is totally believable in 'The Notebook,' thanks to the amazing chemistry these two had on-screen. They later dated for a few years in real life. 

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Adam Sandler and Drew Barrymore - A comedic couple with undeniable chemistry, these actors were in 'The Wedding Singer,' '50 First Dates,' and 'Blended.'

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Amy Adams and Christian Bale - Outstanding performances and an undeniable chemistry between these two actors made 'American Hustle' a great film.

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Rose Byrne and Seth Rogen -

Byrne and Rogen just work extremely well together on-screen, and 'Neighbors' is proof of that.

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Natalie Portman and Jude Law - Featuring one of the most moving breakup scenes of all time, Portman and Law's chemistry made their relationship extremely believable in 'Closer.'

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Zhang Ziyi and Takeshi Kaneshiro - The relationship between their characters in 'House of Flying Daggers' worked amazingly well in the movie because of their chemistry.

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Goldie Hawn and Kurt Russell - The couple's chemistry was visible when they co-starred in 'Swing Shift' in 1984 and followed it up with 'Overboard' in 1987.

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Heath Ledger and Jake Gyllenhaal - Ledger and Gyllenhaal's on-screen chemistry played a big part in the success of 'Brokeback Mountain.'

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Ethan Hawke and Julie Delpy - They pair's chemistry was so visible that they starred in three movies together: 'Before Sunrise,' 'Before Sunset,' and 'Before Midnight.'   

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Elizabeth Taylor and Richard Burton -

Taylor was in 11 films with her eventual husband, Burton, including 'Cleopatra' in 1963 and 'Who's Afraid of Virginia Woolf?' in 1966.

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Clark Gable and Vivien Leigh -

The pair's on-screen chemistry helped to make 'Gone With the Wind' a classic.

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Emma Stone and Andrew Garfield - Stone and Garfield met on the set of 'The Amazing Spider-Man.' They got along so well that they started dating in real life.

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Dev Patel and Freida Pinto - Their chemistry was so strong in 'Slumdog Millionaire' that it developed into a relationship off-screen.

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Natalie Portman and Mila Kunis -

Natalie Portman and Mila Kunis' torrid kissing scene in 'Black Swan' made their on-screen chemistry even more evident. 

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Mickey Rourke and Kim Basinger - Mickey Rourke and Kim Basinger made most people's sexual lives look pretty vanilla in '9 ½ Weeks.'

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Nicolas Cage and Elisabeth Shue -

The heartbreaking story between the two in 'Leaving Las Vegas' works exceptionally well because their connection is so strong on-screen.

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Cameron Diaz and Tom Cruise -

Kidman was not the only actress with whom Cruise had great chemistry. Diaz was the ex-girlfriend you fear in 'Vanilla Sky,' and the pair reunited for the action-packed film 'Knight and Day.'

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Rachel McAdams and Bradley Cooper - Maybe not as strong as with Gaga, but Cooper and McAdams had a pretty good chemistry in 'Aloha.'

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Ryan O’Neal and Ali McGraw -

The pair starred in the poignant 1970 film 'Love Story.'

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