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Murray, 'The Goldbergs' (Jeff Garlin) -

In Jeff Garlin's case, he upset many more of his co-workers on the set of the ABC sitcom 'The Goldbergs,' on which he played the patriarch, Murray. Garlin had allegedly engaged in a pattern of verbal and physical conduct that included behaving in a demeaning and unprofessional manner, touching or hugging people without their consent, and using language that was degrading to women, Vanity Fair reported in December 2021. All of this led to an HR investigation, which Garlin chalked up to a "difference of opinion" between him and Sony Pictures Television, but soon after it was announced that he would be exiting the show. 

In a recent interview with Entertainment Weekly, showrunners Chris Bishop and Alex Barnow explained that for the 10th season of the sitcom, Murray will be dead. "[Murray] will have passed, and we are sort of starting from a place of multiple months removed from his death. The family has already grieved," they said. "It’s an opportunity for this interesting emotional basis for the way people are behaving. But Jeff won’t be in the series this year, and so far the stories have been largely about looking forward rather than looking back.”

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Eddie LeBec, ‘Cheers’ (Jay Thomas) - If you don’t like kissing your on-screen wife, maybe don’t complain to the world on your radio show! Thomas reportedly got loose-lipped on-air about smooching Rhea Perlman, who happened to be listening at the time. His character was soon killed off in a bizarre zamboni accident.

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Edie Britt, ‘Desperate Housewives’ (Nicollette Sheridan) - Edie Britt was killed off in 2009, reportedly due to Sheridan's poor relationship with the cast and crew, her tendency to show up late and forget lines, and her volatile relationship with showrunner Marc Cherry.

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Edie Britt, ‘Desperate Housewives’ (Nicollette Sheridan) - In a lawsuit, Sheridan insisted she was wrongfully terminated due to economic and creative reasons, but the ordeal ended in a mistrial. 

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Professor Maximilian Arturo, ‘Sliders’ (John Rhys-Davies) - The Welsh actor regularly complained about the script for the '90s sci-fi show, describing it as "incomprehensible gibberish." The writers took their revenge on his character halfway through its third season.

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Prue, 'Charmed' (Shannen Doherty) - Doherty has had a reputation for being difficult dating back to 'Beverly Hills, 90210,' and this supernatural drama was no exception. She reportedly clashed with costar Alyssa Milano to the point of no return.

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Prue, 'Charmed' (Shannen Doherty) - The on-screen sisters allegedly fought even worse than sisters off-screen, and the producers had no choice but to kill Prue by the hands of a demonic killer at the end of season three.

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Marissa Cooper, 'The O.C.' (Mischa Barton) - Marissa Cooper dies in a devastating car crash in the third season, following Barton's reputation as an unmanageable on-set personality and her downward spiral into substance abuse and excessive partying.

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Mischa Barton throws up chewed up breakfast cereal - In the creepy scene when she throws up in Cole's tent, she's throwing up breakfast cereal mix that she would hold in her mouth and spit up.

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Dr. Derek Shepherd, ‘Grey’s Anatomy’ (Patrick Dempsey) - McDreamy was killed in a car crash at the end of season 11 after reports that the married Dempsey was having an affair with a staffer. Shonda Rhimes later admitted on 'The Nightly Show' that she's written a character out because of an actor, though she wouldn't say who.

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Dr. Preston Burke, 'Grey's Anatomy' (Isaiah Washington) - The drama of the show is almost as juicy off-screen! Washington's character was dropped from the show after the actor was fired for allegedly using homophobic slurs against costar T.R. Knight. 

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Dr. George O’Malley, ‘Grey’s Anatomy’ (T.R. Knight) - Knight's character was also killed off, though by heroically sacrificing himself to save a woman from an oncoming bus, because he was allegedly stirring up problems on set after the altercation with Washington.

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Harrison Wright, 'Scandal' (Columbus Short) -

Shonda Rhimes' TV universe is once again more scandalous off-screen. Short was arrested twice for alleged domestic violence and substance abuse, and his character was soon murdered off-screen by a government agent.

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Valerie Hogan, 'Valerie' (Valerie Harper) - In one of the most surprising TV exits ever, the eponymous star of the show was killed off due to a salary dispute and the actor's alleged disruptive behavior. Harper ended up suing Lorimar Pictures for a nice $1.8 million payout.

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Charlie Harper, ‘Two and a Half Men’ (Charlie Sheen) - The fastest way to get killed off a show is by making antisemitic remarks about showrunner Chuck Lorre, and calling him a "maggot." Lorre wasn't afraid to kill off the main character!

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Charlie Harper, ‘Two and a Half Men’ (Charlie Sheen) -

Charlie Harper gets hit by a train, and if that wasn't enough, he has a completely disrespectful funeral where it is revealed that he was, among other things, attracted to animals. 

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Libby Smith and Ana Lucia Cortez, ‘Lost’ (Cynthia Watros and Michelle Rodriguez) -

The 2000s phenomenon had two short-tempered stars at the same time. Watros (pictured) and Rodriguez were also both separately arrested for drunk driving in 2005, and on the same night too!

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Libby Smith and Ana Lucia Cortez, ‘Lost’ (Cynthia Watros and Michelle Rodriguez) -

Watros and Rodriguez (pictured) were too much of a menace, and the result was their characters ending up buried next to each other after being shot by the despicable Michael in season two.

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James Evans, Sr., ‘Good Times’ (John Amos) - John Amos became disillusioned with the cheap humor of the show that started off as an important depiction of an African-American family, and after voicing his concerns, his character wasn't even given the courtesy of an on-screen death. 

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Charlie Pace, 'Lost' (Dominic Monaghan) - So much trouble in Hawaiian paradise! Monaghan's much-loved character Charlie had one of the most surprising deaths on the show when he drowned at the end of season three.

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Charlie Pace, ‘Lost’ (Dominic Monaghan) - The actor lead his character to death by publicly venting his frustrations about the cast, adding tension to the already tense situation after his bitter split with costar Evangeline Lilly, and tweeting that leading man Matthew Fox “beats women.” Not ideal!

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Jason Gideon, ‘Criminal Minds’ (Mandy Patinkin) - The actor was quite vocal about this role being his biggest mistake, that it was destructive to his soul and potentially ruined his career. He slowly stopped showing up, forcing the writers to kill his character in an off-screen shooting.

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Aaron Hotchner, 'Criminal Minds' (Thomas Gibson) - Following an altercation with writer/producer Virgil Williams about the script, the show was forced to fire Gibson and write out one of the audiences' favorite characters. Gibson had allegedly been aggressive, moody, and verbally abusive on set for years.

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Jimmy Darmody, ‘Boardwalk Empire’ (Michael Pitt) - Pitt reportedly showed up late, repeatedly forgot his lines, rewrote his dialogue, and constantly questioned his character’s story line. To solve the problem, his character was shot dead in season two.

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Jimmy Darmody, ‘Boardwalk Empire’ (Michael Pitt) - He caused trouble till the end, though, allegedly getting into a fight with costar William Forsythe during his death scene. Even Pitt's own agent got rid of him!

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Susan Ross, 'Seinfeld' (Heidi Swedberg) - George Constanza's fiancée died by licking fatally toxic wedding envelopes, all because Jason Alexander didn't feel that he and Swedberg had good comedy chemistry. 

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Maude Flanders, ‘The Simpsons’ (Maggie Roswell) -

Even animated characters aren't safe! Due to a pay dispute between Fox and Roswell, when the network reportedly failed to even cover her travel costs, Maude Flanders met her maker in a T-shirt gun accident.

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Jenny Humphrey, 'Gossip Girl’ (Taylor Momsen) - According to Hollywood Life, Momsen was written out because of her “unreliable and erratic behavior,” as well as her lackluster performances. Though Jenny didn't die, Momsen's chance at Hollywood might have.

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Jenny Humphrey, 'Gossip Girl' (Taylor Momsen) - Tim Gunn guest-starred as Momsen's fashion mentor on the show, and he's publicly claimed, "What a diva! She was pathetic, she couldn't remember her lines, and she didn't even have that many." 

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Steve Crosetti, ‘Homicide: Life on the Street’ (Jon Polito) -

Polito complained one time too many about his character, and Steve Crosetti soon killed himself by drowning. Polito later apologized and was welcomed back in the film adaptation as a ghost. 

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Pierce Hawthorne, ‘Community’ (Chevy Chase) -

The legendary comedian clashed repeatedly with producers and cast members, making offensive and critical public remarks about the show. He lasted five seasons as Pierce, a narrow-minded character that many believe was based on Chase himself.

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Cordelia Chase, ‘Angel’ (Charisma Carpenter) -

Cordelia had the largest presence across both ‘Buffy the Vampire Slayer’ and its spin-off 'Angel,' but her beloved character suddenly went into a coma and died in the fourth season. What did Carpenter do? She got pregnant!

See also: Stars who were told they would never make it

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