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Lil Nas X & Billy Ray Cyrus - Lil Nas X scored a viral hit with 'Old Town Road,' and with the help of Billy Ray Cyrus it got back on the Billboard Country Chart, while also introducing he young rapper to a whole new demographic. 

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Lil Nas X & RM - The K-pop star's addition to the song not only makes Lil Nas X a huge star in Korea now, but 'Seoul Town Road' became the number one trending topic on Twitter worldwide. 

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Sting & Shaggy - Sting and Shaggy teamed up last year, on the collab album '44/876.' It won Best Reggae Album at the 61st Grammy Awards.

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Santana & Rob Thomas - Rob Thomas is the lead singer of alternative rock band Matchbox Twenty. He collabed with Santana on the smash hit, 'Smooth.'

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Avicii & Aloe Blacc - The late DJ was getting tired of his bass-crazy dance sets, and brought in Aloe Blacc for a mix of EDM and folk on 'Wake Me Up.'

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J Balvin, Willy William & Beyonce - J Balvin has a few cross-genre collabs, like his 2017 collaboration with Beyoncé: 'Mi Gente.' Bey got involved to help raise charity funds for Puerto Rico.

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R.E.M. & KRS-One - In 1991, alternative rockers R.E.M. worked with rapper KRS-One, collaborating on the comedic track 'Radio Song.'

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Drake & Romeo Santos - Drake is another artist who has stepped outside his genre, like on 'Odio,' a Spanish-language Bachata collab with Romeo Santos.

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Lou Reed & Metallica - Lou Reed and Metallica joined forces on 'Lulu,' an album that's both beloved and hated. Reed's spoken word verses are read over Metallica's raging guitars.

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Quavo, Cardi B, & Madonna - Last year, Migos member Quavo raised eyebrows by bringing Cardi B and Madonna together, on the opera-rap track 'Champagne Rose.'

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RUN-DMC & Aerosmith - Aerosmith's 'Walk This Way' was already a hit, but RUN-DMC's version took the song to the next level. At first, the rappers didn't even want to do the song.

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The Lonely Island & Michael Bolton - The Lonely Island are a comedy group with plenty of crazy collabs. Maybe their weirdest is with Michael Bolton, on the club rap collab 'Jack Sparrow.'

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David Bowie & Bing Crosby - Bing Crosby posthumous collab with David Bowie is unlikely and iconic. The Christmas tune combines Bowie's space rock with Crosby's holiday charm.

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Nick Cave & Kylie Minogue - Kylie was recovering from poor record sales when she teamed up with experimentalist Nick Cave. The song was a hit, and revived both of their careers.

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Jay-Z & Linkin Park - In 2004, Jay-Z and Linkin Park took the world by storm with 'Collision Course,' an EP combining Jay's street-smart raps with the band's hardcore rock.

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Chuck D & Anthrax - 'Bring the Noise' was already a standout single from Public Enemy. Eventually, thrash metal outfit Anthrax covered the single with Chuck D.

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DMC & Sarah Mclachlan - Rapper DMC said Sarah McLachlan's music got him through some dark patches. He reached out to the singer-songwriter, and they collabed on the track 'Just Like Me.'

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The Jacksons & Mick Jagger - Though it's credited to the Jacksons, 'State of Shock' is basically a duet between MJ and Mick Jagger.

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Brad Paisley & LL Cool J - 'Accidental Racist' is a bizarre country rap track. LL Cool J raps about gold chains, while Brad Paisley hopes to wear the Confederate flag in peace.

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Dido & Kendrick Lamar - Dido was actually sampled on 'Stan' by Eminem, which makes her collab with Kendrick Lamar is a little more authentic. The two dueted on her song 'Let Us Move On.'

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Nelly & Tim McGraw - The worlds of rap and country collided on 'Over and Over,' a smash hit from Nelly and Tim McGraw.

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BlackPink & Dua Lipa - Dua Lipa had already written the majority of 'Kiss and Make Up,' when she invited BlackPink to finish the track. It's an artful blend of pop and K-pop.

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Sonic Youth & Chuck D - Chuck D really gets around, and sounded right at home on 'Kool Thing,' a collab with rock band Sonic Youth.

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Amerie & Se7en - Amerie paid tribute to her Korean heritage on 'Lose Control,' a collab with K-pop musician Se7en.

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Kanye West & Adam Levine - Mr. West has frequently stepped outside of his comfort zone, but his duet with Adam Levine on 'Heard 'Em Say' is perhaps his most perfect pop-rap performance.

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Dizzee Rascal & Florence and the Machine - Out of the blue, British rapper Dizzee Rascal debuted a collab with Florence and the Machine live at the 2010 BRIT Awards. The song is titled 'You Got the Dirtee Love.'

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Freddie Mercury & Montserrat Caballe - After 'Bohemian Rhapsody,' the Queen front man continued his operatic antics with Spanish soprano Montserrat Caballé. In 1998, they released the joint album 'Barcelona.'

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Enrique Iglesias & Sean Paul - Jamaican star Sean Paul joined forces with Enrique Iglesias on 'Bailando,' a blend of flamenco, reggaeton, and good old-fashioned pop.

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Neneh Cherry & Youssou N'Dour - Swedish star Neneh Cherry scored a hit with Senegalese singer Youssou N'Dour. Their duet, '7 Seconds,' is a trilingual hit mixing rap with downtempo.

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Luis Fonsi, Daddy Yankee & Justin Bieber - You've probably heard this one before. JB took Luis Fonsi's Spanish-language hit and brought it to a wider audience. It became the biggest song of 2017.

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Kylie Minogue & Gente de Zona -

Last year Kylie enlisted Gente de Zona, a Cuban reggaeton duo, to collaborate on her single 'Stop Me from Falling.'

From here, listen to these artists with posthumous collabs. 

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