Rosie O’Donnell has shared new details about her weight-loss journey, saying she has lost about 65 lbs (29.5 kg) over three years while taking the GLP-1 drug Mounjaro. Speaking on the July 27 episode of ‘Bleep! with Ana Navarro,’ the 64-year-old comedian said she deliberately chose a slow approach.
O’Donnell said she spent one year on the lowest 2.5 mg dose, another year on 5 mg, and is now finishing a year on 7.5 mg. She said she plans to increase her dosage “one more time” before stopping.
The star said gradual weight loss works better for her because rapid changes can feel overwhelming. She also said she has not experienced side effects, which she partly linked to increasing the dose slowly under medical supervision.
O’Donnell previously told People she began taking Mounjaro after being diagnosed with type 2 diabetes, calling the medication a “miracle drug.” Her comments highlight a growing conversation around GLP-1 drugs, rapid weight loss, and how differently the body can respond.
In recent years, there has been a boom in people using Ozempic, Mounjaro, and other medications in the same class. For some, they are a lifeline for diabetes or weight-related health conditions. For others, their appeal lies in the rapid weight loss they can bring. But what happens inside the body when weight drops quickly? Click on to find out.