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See Also
See Again
© Shutterstock
0 / 31 Fotos
XX and XY
- In humans, as well as many other mammals, females have two X chromosomes, and men have one X and one Y chromosome.
© Shutterstock
1 / 31 Fotos
Chromosomes
- Looking at human biology at its most basic, we can break it down like this: in the nucleus (control center) of a human cell, each DNA molecule is packed into a long thread called a chromosome.
© Shutterstock
2 / 31 Fotos
Chromosomes
- Most human cells contain 23 pairs of chromosomes, with half of these coming from each parent. There are 22 pairs of "autosomes," while the last (23rd) pair are the sex chromosomes.
© Shutterstock
3 / 31 Fotos
Y chromosome
- A symbol of masculinity, the Y chromosome is determined paternally. The sex of humans and other mammals depends on the gene passed on by the male.
© Shutterstock
4 / 31 Fotos
Deterioration
- However, it appears the Y chromosome is deteriorating at an alarming rate, and in a few million years it could disappear completely.
© Shutterstock
5 / 31 Fotos
Evolve or become extinct
- Unless we evolve to produce a new sex gene, the degeneration of the Y chromosome could eventually lead to our extinction as a human race.
© Shutterstock
6 / 31 Fotos
Gene function
- The X chromosome contains around 900 genes that do all kinds of jobs. In comparison, the Y chromosome contains about 55 genes, as well as repetitive DNA that doesn't seem to have a function.
© Shutterstock
7 / 31 Fotos
Gene function
- However, the Y chromosome remains important. It contains a gene that's responsible for starting male development in the embryo.
© Shutterstock
8 / 31 Fotos
Gene function
- This is because the Y chromosome contains the SRY gene, which acts as a "master switch" for the development of human testes (male gonads).
© Shutterstock
9 / 31 Fotos
Conception
- Around 12 weeks after conception, these genes turn on to make male hormones (testosterone and its other derivatives), ensuring the baby develops as a boy.
© Shutterstock
10 / 31 Fotos
Identification
- The SRY gene and its action was first identified in 1990. It was discovered that it triggers a genetic pathway beginning with something called the SOX9 gene, which determines the male sex in all vertebrates.
© Shutterstock
11 / 31 Fotos
A fundamental flaw
- In the early days of our species, the Y chromosome was the same size as the X chromosome, and it contained all the same genes.
© Shutterstock
12 / 31 Fotos
A fundamental flaw
- However, it seems that Y chromosomes have a fundamental flaw. Other chromosomes have two copies in each cell, allowing genes to recombine and lose harmful mutations.
© Shutterstock
13 / 31 Fotos
Father to son
- Y chromosomes are only ever present as a single copy, passed on from fathers to their sons. This means that the "shuffling" of genes doesn't happen from one generation to another.
© Shutterstock
14 / 31 Fotos
Degeneration
- Without the benefits of recombination, Y chromosomal genes degenerate over time and are eventually lost from the genome.
© Shutterstock
15 / 31 Fotos
Slowing gene loss
- Despite this, it appears the Y chromosome has some mechanisms to slow down the rate of gene loss. One Danish study sequenced the Y chromosome from 62 men and found interesting results.
© Shutterstock
16 / 31 Fotos
Gene amplification
- The results showed the Y chromosome is prone to large-scale, structural rearrangements, allowing for something called "gene amplification."
© Shutterstock
17 / 31 Fotos
Gene amplification
- This amplification allows the Y chromosome to acquire multiple copies of genes that promote healthy sperm function and mitigate gene loss.
© Shutterstock
18 / 31 Fotos
Palindromes
- What's more, it appears the Y chromosome has developed things called "palindromes"—sequences that read the same forwards as well as backwards.
© Shutterstock
19 / 31 Fotos
Palindromes
- These palindromes protect the gene from degrading further. Researchers recorded a high rate of "gene conversion events" within palindromic sequences.
© Shutterstock
20 / 31 Fotos
Gene conversion events
- These events are a copy and paste process within the gene. They allow for damaged genes to be repaired using an undamaged copy as a template.
© Shutterstock
21 / 31 Fotos
Disappearance
- Whether the Y chromosome will disappear or not is a matter of debate in the scientific community. Some feel the mutations taking place are enough to save it, while others argue its demise is inevitable.
© Shutterstock
22 / 31 Fotos
Adaptation in nature
- There is some good news, however: it's already happened to the male vole in Eastern Europe and the spiny rat in Japan, and they've adapted.
© Shutterstock
23 / 31 Fotos
Adaptation in nature
- These rodents have developed a new male-determining gene in an evolutionary response to the decline of the Y chromosome.
© Shutterstock
24 / 31 Fotos
Good news
- The good news is that even if the Y chromosome does eventually die out, it doesn't necessarily mean men themselves will disappear.
© Shutterstock
25 / 31 Fotos
Normal human reproduction
- Even if the Y chromosome did disappear, males and females are both still necessary for human reproduction.
© Shutterstock
26 / 31 Fotos
Assisted reproduction
- Interestingly, many of the genes the Y chromosome carries are not necessary when you use assisted reproduction methods.
© Shutterstock
27 / 31 Fotos
Genetic engineering
- This could mean that genetic engineering could be used to find a replacement to the function of the Y chromosome. If this happened, it could allow same-sex couples or infertile men to conceive.
© Shutterstock
28 / 31 Fotos
Natural reproduction
- However, even if this became possible, it's unlikely humans would one day collectively decide to stop reproducing naturally.
© Shutterstock
29 / 31 Fotos
We just don't know
- Right now, it's uncertain that the Y chromosome will disappear at all. And even if it does, we have a few million years to figure it out! Sources: (ScienceAlert) (IFLScience) (Deseret News) (AAAS) (Indy100)
© Shutterstock
30 / 31 Fotos
© Shutterstock
0 / 31 Fotos
XX and XY
- In humans, as well as many other mammals, females have two X chromosomes, and men have one X and one Y chromosome.
© Shutterstock
1 / 31 Fotos
Chromosomes
- Looking at human biology at its most basic, we can break it down like this: in the nucleus (control center) of a human cell, each DNA molecule is packed into a long thread called a chromosome.
© Shutterstock
2 / 31 Fotos
Chromosomes
- Most human cells contain 23 pairs of chromosomes, with half of these coming from each parent. There are 22 pairs of "autosomes," while the last (23rd) pair are the sex chromosomes.
© Shutterstock
3 / 31 Fotos
Y chromosome
- A symbol of masculinity, the Y chromosome is determined paternally. The sex of humans and other mammals depends on the gene passed on by the male.
© Shutterstock
4 / 31 Fotos
Deterioration
- However, it appears the Y chromosome is deteriorating at an alarming rate, and in a few million years it could disappear completely.
© Shutterstock
5 / 31 Fotos
Evolve or become extinct
- Unless we evolve to produce a new sex gene, the degeneration of the Y chromosome could eventually lead to our extinction as a human race.
© Shutterstock
6 / 31 Fotos
Gene function
- The X chromosome contains around 900 genes that do all kinds of jobs. In comparison, the Y chromosome contains about 55 genes, as well as repetitive DNA that doesn't seem to have a function.
© Shutterstock
7 / 31 Fotos
Gene function
- However, the Y chromosome remains important. It contains a gene that's responsible for starting male development in the embryo.
© Shutterstock
8 / 31 Fotos
Gene function
- This is because the Y chromosome contains the SRY gene, which acts as a "master switch" for the development of human testes (male gonads).
© Shutterstock
9 / 31 Fotos
Conception
- Around 12 weeks after conception, these genes turn on to make male hormones (testosterone and its other derivatives), ensuring the baby develops as a boy.
© Shutterstock
10 / 31 Fotos
Identification
- The SRY gene and its action was first identified in 1990. It was discovered that it triggers a genetic pathway beginning with something called the SOX9 gene, which determines the male sex in all vertebrates.
© Shutterstock
11 / 31 Fotos
A fundamental flaw
- In the early days of our species, the Y chromosome was the same size as the X chromosome, and it contained all the same genes.
© Shutterstock
12 / 31 Fotos
A fundamental flaw
- However, it seems that Y chromosomes have a fundamental flaw. Other chromosomes have two copies in each cell, allowing genes to recombine and lose harmful mutations.
© Shutterstock
13 / 31 Fotos
Father to son
- Y chromosomes are only ever present as a single copy, passed on from fathers to their sons. This means that the "shuffling" of genes doesn't happen from one generation to another.
© Shutterstock
14 / 31 Fotos
Degeneration
- Without the benefits of recombination, Y chromosomal genes degenerate over time and are eventually lost from the genome.
© Shutterstock
15 / 31 Fotos
Slowing gene loss
- Despite this, it appears the Y chromosome has some mechanisms to slow down the rate of gene loss. One Danish study sequenced the Y chromosome from 62 men and found interesting results.
© Shutterstock
16 / 31 Fotos
Gene amplification
- The results showed the Y chromosome is prone to large-scale, structural rearrangements, allowing for something called "gene amplification."
© Shutterstock
17 / 31 Fotos
Gene amplification
- This amplification allows the Y chromosome to acquire multiple copies of genes that promote healthy sperm function and mitigate gene loss.
© Shutterstock
18 / 31 Fotos
Palindromes
- What's more, it appears the Y chromosome has developed things called "palindromes"—sequences that read the same forwards as well as backwards.
© Shutterstock
19 / 31 Fotos
Palindromes
- These palindromes protect the gene from degrading further. Researchers recorded a high rate of "gene conversion events" within palindromic sequences.
© Shutterstock
20 / 31 Fotos
Gene conversion events
- These events are a copy and paste process within the gene. They allow for damaged genes to be repaired using an undamaged copy as a template.
© Shutterstock
21 / 31 Fotos
Disappearance
- Whether the Y chromosome will disappear or not is a matter of debate in the scientific community. Some feel the mutations taking place are enough to save it, while others argue its demise is inevitable.
© Shutterstock
22 / 31 Fotos
Adaptation in nature
- There is some good news, however: it's already happened to the male vole in Eastern Europe and the spiny rat in Japan, and they've adapted.
© Shutterstock
23 / 31 Fotos
Adaptation in nature
- These rodents have developed a new male-determining gene in an evolutionary response to the decline of the Y chromosome.
© Shutterstock
24 / 31 Fotos
Good news
- The good news is that even if the Y chromosome does eventually die out, it doesn't necessarily mean men themselves will disappear.
© Shutterstock
25 / 31 Fotos
Normal human reproduction
- Even if the Y chromosome did disappear, males and females are both still necessary for human reproduction.
© Shutterstock
26 / 31 Fotos
Assisted reproduction
- Interestingly, many of the genes the Y chromosome carries are not necessary when you use assisted reproduction methods.
© Shutterstock
27 / 31 Fotos
Genetic engineering
- This could mean that genetic engineering could be used to find a replacement to the function of the Y chromosome. If this happened, it could allow same-sex couples or infertile men to conceive.
© Shutterstock
28 / 31 Fotos
Natural reproduction
- However, even if this became possible, it's unlikely humans would one day collectively decide to stop reproducing naturally.
© Shutterstock
29 / 31 Fotos
We just don't know
- Right now, it's uncertain that the Y chromosome will disappear at all. And even if it does, we have a few million years to figure it out! Sources: (ScienceAlert) (IFLScience) (Deseret News) (AAAS) (Indy100)
© Shutterstock
30 / 31 Fotos
The end of men? The Y male chromosome is deteriorating at an alarming rate
Do they have a place in the future?
© Shutterstock
The chromosomes that demonstrate the sex of a human are XX and XY. Indeed, we get one of each from our parents. Women can only pass on the X chromosome, while it's male sperm that determines whether a baby will be of female sex (X) or male sex (Y). So what happens if the Y chromosome is in decline? Does it mean there will be less men on the planet, and does this have implications for our species and its survival?
Curious? Click on to learn more about what could happen if the Y chromosome is no more.
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