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President Dwight D. Eisenhower and Vice President Richard Nixon -

While Nixon was publicly loyal to Eisenhower, they disagreed on several issues, such as sending US troops to aid the French during the decolonization of South Vietnam as well as the Supreme Court's decision to desegregate public schools. Nixon supported both, while Eisenhower was opposed.

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President Dwight D. Eisenhower and Vice President Richard Nixon -

Things really escalated in 1960 when Eisenhower was asked to name a major contribution Nixon had made to his administration and answered, "Well, if you give me a week I might think of one."

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President Dwight D. Eisenhower and Vice President Richard Nixon -

They eventually reconciled when Nixon's daughter Julie married Eisenhower's grandson David in 1968.

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President Franklin D. Roosevelt and Vice President John Nance Garner -

Roosevelt initially got along well with his VP. In his seventies, John Nance Garner was a hard-drinking Texan who once claimed that the vice presidency wasn't "worth a bucket of warm spit."  He also eventually soured on FDR's liberal, New Deal program, which clashed with his conservative perspective.

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President Franklin D. Roosevelt and Vice President John Nance Garner -

Then, with the 1940 election approaching, Garner figured that it was now or never if he wanted to be president. So he further alienated Roosevelt with isolationist foreign policy views.

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President Franklin D. Roosevelt and Vice President John Nance Garner -

When Garner openly challenged Roosevelt, he was outmaneuvered when the president allowed himself to be "drafted" as a candidate, a strategy that enabled him to avoid scrutiny for breaking the unwritten "two term" rule that was presidential tradition. Garner essentially retired from politics and went back to Texas.

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President Andrew Jackson and Vice President John C. Calhoun -

President Andrew Jackson and Vice President John C. Calhoun immediately began to clash over the issue of tariffs, which the VP felt discriminated against Southern states and favored the North. This dispute escalated to the point that Calhoun threatened to use the legal concept of "nullification," in which a state ignored a federal law it felt was unconstitutional.

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President Andrew Jackson and Vice President John C. Calhoun -

Calhoun even threatened to secede from the Union, a threat that prompted Jackson to ask Congress to pass the 1833 Force Bill, which allowed the federal government to use military action to force state compliance. By then, Calhoun was a senator, having resigned as VP.

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President Andrew Jackson and Vice President John C. Calhoun -

At one point during the dispute, Jackson famously stated: "John Calhoun, if you secede from my nation I will secede your head from the rest of your body."

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President Thomas Jefferson and Vice President Aaron Burr -

In 1800, the presidential electoral process faced a big dilemma. After all votes were cast and electors designated, the two Republican Party candidates, Thomas Jefferson and Aaron Burr, were tied with 73 electoral votes. Back then, parties didn't designate a combined ticket, so it was possible for electors to cast two votes for any of four candidates. The one with the clear majority would win, and the one who came in second would become vice president. Jefferson became president, and Burr became vice president.

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President Thomas Jefferson and Vice President Aaron Burr -

Burr was immediately ostracized by Jefferson, who suspected that he had attempted to obtain the presidency for himself during the lengthy election. Any of Burr's requests for official appointments in the new cabinet were ignored, and he was quickly isolated. By 1804, he knew he would be dropped. When his unsuccessful 1804 campaign for Governor of New York was impacted negatively by Alexander Hamilton, Burr's political frustration led to a notorious duel that killed the former Secretary of the Treasury.

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President Thomas Jefferson and Vice President Aaron Burr -

Although dueling was illegal, Burr was never tried and all charges against him were eventually dropped. Nevertheless, killing Hamilton ended Burr's political career. The election of 1800 caused such turmoil that the 12th Amendment to the Constitution was passed, which would allow electors to vote for a president and vice president instead of two votes for president.

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President William McKinley and Vice President Theodore Roosevelt -

William McKinley never really liked Teddy Roosevelt. Roosevelt served as assistant secretary of the Navy under President McKinley, and in 1898 helped plan the highly successful naval war against Spain. However, McKinley felt his demands for war during his administration were really about Roosevelt wanting to get military service on his political resume. Roosevelt once said of the president, "He has all the backbone of a chocolate éclair."

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President William McKinley and Vice President Theodore Roosevelt -

Returning a war hero, Roosevelt was elected New York's governor in 1898. But the New York state party leadership disliked his ambitious agenda and convinced McKinley to choose him as his running mate in the 1900 presidential election.

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President William McKinley and Vice President Theodore Roosevelt -

Roosevelt served as the 25th VP under President McKinley for six months in 1901. He assumed the presidency after McKinley's assassination, and stayed in office until 1909.

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President John F. Kennedy and Vice President Lyndon B. Johnson -

In 1960, JFK chose Senator Lyndon B. Johnson, who had finished second on the presidential ballot, as his running mate. Johnson, a Protestant Texan, provided geographical and religious balance to a ticket led by a Catholic Northeasterner, but many liberals didn't like the pick.

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President John F. Kennedy and Vice President Lyndon B. Johnson -

JFK rarely met with Johnson personally, and his brother, Attorney General Robert Kennedy, openly feuded with him. The VP mostly went on assignments around the world, which he felt was to get him out of Washington.

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President John F. Kennedy and Vice President Lyndon B. Johnson -

This resulted in a deep resentment and estrangement from the Kennedy's. After JFK's assassination, Johnson served as president from 1963 to 1969.

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President Calvin Coolidge and Vice President Charles G. Dawes -

Dawes wasn't Coolidge's first choice for VP. The position was actually offered to another politician, who turned it down. On top of that, Dawes' stubbornly opinionated attitude was at odds with the president known as "Silent Cal."

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President Calvin Coolidge and Vice President Charles G. Dawes -

While the two won in a landslide, their relationship quickly turned sour. In accordance with a tradition dating back to 1789, Dawes was to deliver a brief Inaugural Address to the Senate. His lengthy tirade against Senate rules stole headlines and the spotlight from the Inaugural Address that Coolidge delivered afterward. This didn't sit too well with Coolidge.

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President Bill Clinton and Vice President Al Gore -

Initially quite close during their two successful presidential campaigns, Bill Clinton and Al Gore drifted apart as several scandals engulfed Clinton's second term.

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President Bill Clinton and Vice President Al Gore -

As early as 1999, Gore publicly criticized the president for his conduct concerning his affair with White House intern Monica Lewinsky. Clinton also began to be irritated by this, and believed that Gore wanted to prove that he could get elected on his own.

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President Bill Clinton and Vice President Al Gore -

When Gore lost the 2000 election, he blamed Clinton's personal conduct for the loss, igniting a tense White House confrontation. They would later patch up their relationship after 9/11.

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President John Adams and Vice President Thomas Jefferson -

It was inevitable that Adams and Jefferson wouldn't get along, as Adams was a Federalist and Jefferson was a Republican. However, their election was the result of the second-place finisher in electoral votes being elected vice president, regardless of party.

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President John Adams and Vice President Thomas Jefferson -

Despite their differences, their personal relationship remained civil until Adams' last-minute appointments of individuals of his own party before Jefferson's inauguration.

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President John Adams and Vice President Thomas Jefferson -

This was seen as an attempt to sabotage Jefferson's vice presidency, and he stopped communicating with Adams for 10 years. However, they rekindled their friendship in 1811, which would last until their deaths, coincidentally on the same day: July 4, 1826.

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President Richard Nixon and Vice President Spiro Agnew -

Nixon wanted to choose a more effective vice president for his 1972 reelection campaign, but couldn't since Agnew was popular with conservatives.

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President Richard Nixon and Vice President Spiro Agnew -

Their relationship deteriorated even further when Agnew resigned in 1973 after pleading no contest to a charge of federal tax evasion following an investigation by the Justice Department.

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President Richard Nixon and Vice President Spiro Agnew -

Nixon and Agnew didn't speak again after his resignation, though Agnew did attend Nixon's funeral in 1994.

Sources: (Ranker) (Business Insider) 

See also: Surprising facts about all 46 US presidents 

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