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30. Prednisone -

Prednisone is a glucocorticoid used in the treatment of asthma and COPD, among other conditions. The total of Prednisone prescriptions in the US amount to 18,201,857.

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29. Meloxicam -

Meloxicam is a nonsteroidal anti-inflammatory drug that is often prescribed in the treatment of osteoarthritis and rheumatoid arthritis. A total of 18,859,721 prescriptions were dispensed in the US.

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28. Insulin Glargine -

Insulin Glargine is a type of injected medical insulin. It's used to manage type I and type II diabetes. It was prescribed 18,983,905 times.

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27. Apixaban -

Apixaban is an anticoagulant used in the treatment and prevention of blood clots. American doctors prescribed it a total of 19,420,949 times. 

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26. Amoxicillin -

Amoxicillin is a popular penicillin antibiotic used to treat a number of bacterial infections. The total of Amoxicillin prescriptions in the US amount to 20,465,164.

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25. Fluticasone -

Fluticasone is a glucocorticoid used to treat rhinosinusitis and allergies. A total of 22,557,458 prescriptions were dispensed by American doctors. 

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24. Furosemide -

Furosemide is a diuretic used in the treatment of edema caused by a number of conditions, including congestive heart failure and liver disease. It was prescribed 23,067,424 times. 

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23. Acetaminophen; Hydrocodone -

Acetaminophen, also known as paracetamol is a popular non-opioid analgesic and antipyretic drug. Hydrocodone, on the other hand, is an opioid painkiller. Prescriptions of both drugs amount to 23,521,228.

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22. Fluoxetine -

This antidepressant, sold under the brand name Prozac, was prescribed 24,014,263 times. 

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21. Bupropion -

Bupropion is an antidepressant that is also used to support smoking cessation. The total of Bupropion prescriptions in the US amount to 25,197,923.

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20. Tamsulosin -

Tamsulosin is used to treat benign prostatic hyperplasia and chronic prostatitis. This drug was prescribed 25,306,357 times. 

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19. Simvastatin -

Simvastatin is a statin used to lower lower "bad" cholesterol (LDL) levels. A total of 26,459,069 prescriptions were dispensed by US doctors. 

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18. Trazodone -

Trazodone is a popular antidepressant used to treat depressive and anxiety disorders. American doctors prescribed it 27,363,318 times.  

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17. Montelukast -

Montelukast is a preventative drug used in the treatment of asthma. The total of Montelukast prescriptions in the US amount to 29,187,952.

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16. Pantoprazole -

Pantoprazole is a proton-pump inhibitor used to in the treatment of acid reflux, and gastro-esophageal reflux disease, and heartburn. Americans were prescribed this drug 30,670,528 times. 

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15. Escitalopram -

This popular antidepressant, sold under the band names Cipralex and Lexapro, was prescribed 30,750,612 times. 

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14. Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate -

This central nervous system stimulant is used in the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy (sleep disorder). A total of 34,690,297 prescriptions were dispensed .

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13. Rosuvastatin -

Rosuvastatin is a statin used in the prevention of cardiovascular disease by lowering bad cholesterol (LDL) and triglycerides levels. The drug was prescribed 37,095,971 times. 

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12. Hydrochlorothiazide -

Hydrochlorothiazide is a diuretic used to treat edema and hypertension. The total of Hydrochlorothiazide prescriptions amount to 38,153,288. 

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11. Sertraline -

Sertraline is an antidepressant of the serotonin reuptake inhibitor (SSRI) class. A total of  39,891,990 prescriptions were dispensed .

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10. Gabapentin -

Gabapentin is an anticonvulsant that is often used to treat seizures and neuropathic pain. Americans were prescribed Gabapentin 40,141,486 times.

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9. Omeprazole -

Omeprazole is a popular proton pump inhibitor used to treat a number of gastric issues, including indigestion, heartburn, and acid reflux. A total of 52,132,950 prescriptions were dispensed by doctors in the US.

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8. Losartan -

Losartan is an angiotensin II receptor blocker used to treat high blood pressure. The drug was prescribed 53,555,510 times. 

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7. Albuterol -

Albuterol or Salbutamol, which is sold under the brand name Ventolin, is a bronchodilator used to treat asthma and other breathing issues. A total of 59,075,269 prescriptions were issued.

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6. Metoprolol -

Metoprolol is a beta blocker used to regulate heart rate, often in people with angina and hypertension. It was prescribed by doctors 65,245,216 times.

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5. Amlodipine -

This popular calcium channel blocker is used to treat high blood pressure. A total of 70,766,211 prescriptions were dispensed by doctors.

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4. Levothyroxine -

This drug, used in the treatment of hypothyroidism (underactive thyroid gland) was prescribed 82,431,914 times.

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3. Lisinopril -

Lisinopril is popular drug used to lower high blood pressure (hypertension). The total of Lisinopril prescriptions amount to 82,513,967.

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2. Metformin -

Metformin is usually prescribed to people with type 2 diabetes to help control blood sugar levels. This drug was prescribed a total of 86,747,907 times. 

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1. Atorvastatin -

Atorvastatin is the most prescribed drug in the US. It's a statin, used to prevent cardiovascular disease by treating high blood cholesterol. A total of 27,935,702 people have been prescribed the drug 109,582,746 times.

Sources: (ClinCalc) (Statista) (Agency for Healthcare Research and Quality) (Insider Monkey) (SingleCare)

See also: Signs you might be taking too many meds

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