The pair starred in the poignant 1970 film 'Love Story.'
Roberts and Gere's on-screen chemistry in 'Pretty Woman' and 'Runaway Bride' was visible.
The pair's on-screen chemistry helped to make 'Gone With the Wind' a classic.
Natalie Portman and Mila Kunis' torrid kissing scene in 'Black Swan' made their on-screen chemistry even more evident.
Cruise and Kidman's on- and off-screen romance was huge in the '90s, as they starred in three films together. The last of which, 'Eyes Wide Shut', is often suspected as a major factor in the dissolution of their marriage.
Taylor was in 11 films with her eventual husband, Burton, including 'Cleopatra' in 1963 and 'Who's Afraid of Virginia Woolf?' in 1966.
Kidman was not the only actress with whom Cruise had great chemistry. Diaz was the ex-girlfriend you fear in 'Vanilla Sky,' and the pair reunited for the action-packed film 'Knight and Day.'
Chastain and Isaac already appeared as a couple in the 2014 film 'A Most Violent Year,' and are co-starring in the new HBO miniseries 'Scenes From a Marriage.' While some might speculate a sexual connection between the two, Chastain clarified that they've been good friends for more than half of their lives. They went to college together and are extremely close, which is why they seem so comfortable and playful with each other.
Byrne and Rogen just work extremely well together on-screen, and 'Neighbors' is proof of that.
The heartbreaking story between the two in 'Leaving Las Vegas' works exceptionally well because their connection is so strong on-screen.
Sandra Bullock and Keanu Reeves starred together in the movies 'Speed' (1994) and 'The Lake House' (2006). Their romances were so believable that fans speculated for years it was more than acting. Bullock addressed the rumors once and for all in a recent interview with Esquire and stated unequivocally that they'd never dated. However, she did reveal to Ellen DeGeneres in 2018 that she had a crush on Reeves when they were filming 'Speed.' When Reeves was asked if had been aware of this he said no, and added: "She obviously didn't know I had a crush on her either."
When it comes to the hit sitcom 'New Girl,' Jessica and Nick were the couple that was always meant to be. Fans rooted for them throughout all seven seasons, and the writers managed to drag their love story out for years. In the new podcast 'Welcome to Our Show,' which features Deschanel and two of her co-stars discussing all the behind-the-scenes magic, Deschanel revealed that the chemistry between her and Jake Johnson was palpable on set. In fact, the writers actually told her that they had "too much" chemistry! This led them to separate Nick and Jess's storylines so they could allow the relationship to develop more slowly over several seasons.
On-screen chemistry between actors can make or break a film. Some pairs work so well together that it's hard to believe they are not romantically involved off-screen. While this is sometimes the case, the vast majority simply have an amazingly genuine on-screen chemistry.
Click through the gallery and get to know some to the best ones.
On-screen couples with great chemistry
Some have become couples in real life
MOVIES Couples
On-screen chemistry between actors can make or break a film. Some pairs work so well together that it's hard to believe they are not romantically involved off-screen. While this is sometimes the case, the vast majority simply have an amazingly genuine on-screen chemistry.
Click through the gallery and get to know some to the best ones.